Description

Methanesulfonato(Tricyclohexylphosphine)(2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(II) Dichloromethane Adduct is a highly specialized, air-stable palladium catalyst pre-catalyst, designed for superior performance in demanding cross-coupling reactions. Its value lies in the combination of the bulky, electron-rich tricyclohexylphosphine ligand and the 2'-amino-1,1'-biphenyl-2-yl group, which facilitates rapid oxidative addition and enhances catalytic activity and selectivity. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable and efficient catalysts for constructing complex carbon-carbon and carbon-heteroatom bonds under mild conditions.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions in the production of active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Used to create novel heterocyclic compounds and complex molecular architectures for new crop protection agents.
• Advanced Material Fabrication: Enables the synthesis of conjugated polymers and organic electronic materials through efficient cross-coupling.
• Process Chemistry & Scale-up: Its stability makes it suitable for optimizing and scaling up coupling reactions from laboratory to pilot plant scale.
• Methodology Development in Academia: A valuable tool for developing new catalytic protocols and exploring challenging bond-forming reactions.
• Fine Chemical Production: Catalyzes the synthesis of specialty chemicals, flavors, and fragrances requiring high selectivity.

Basic Information

Product Name	Methanesulfonato(Tricyclohexylphosphine)(2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(II) Dichloromethane Adduct
CAS No.	1445086-12-3
Molecular Formula	C37H52NO3PPdS • x(CH2Cl2)
Molecular Weight	Contact for details
Synonyms	Palladium Methanesulfonate Tricyclohexylphosphine 2'-Amino-1,1'-Biphenyl-2-Yl Adduct; (2'-Aminobiphenyl-2-yl)(methanesulfonato)(tricyclohexylphosphine)palladium(II) Dichloromethane Solvate; Buchwald-Hartwig Catalyst Precursor; Pd-PCy3 Aminobiphenyl Complex; Methanesulfonato(2'-amino-1,1'-biphenyl-2-yl)(tricyclohexylphosphine)palladium(II); [Pd(PCy3)(2-NH2-biphenyl)](OMs) • CH2Cl2; CAS 1445086-12-3.
EINECS	Contact for details

Quality Control

Every batch of our palladium catalyst is manufactured and analyzed under strict quality control protocols to ensure high purity and consistent catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as palladium content, purity by NMR and HPLC, and residual solvent levels. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) to maintain long-term stability and prevent decomposition. The material is light-sensitive and should be handled in a controlled environment to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline or amorphous solid
Identification (IR)	Conforms to structure
Palladium (Pd) Content	Contact for details
Purity (HPLC)	≥95% (Area %)
Solvent Content (Residual CH2Cl2)	By specification

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.