Description

Ruphos Pd G3 CAS NO 1445085-77-7 is a highly active, third-generation palladium precatalyst featuring the Ruphos ligand, designed for demanding cross-coupling reactions. This compound matters because it offers superior performance in challenging transformations, including the coupling of sterically hindered substrates and less reactive aryl chlorides, providing researchers and process chemists with a reliable tool for complex bond formation. It is essential for professionals in pharmaceutical research, agrochemical development, and advanced materials science who require robust and efficient catalytic systems for small-molecule synthesis.

Application

Ruphos Pd G3 is a versatile catalyst precursor with applications across advanced synthetic chemistry. Key uses include:

• Buchwald-Hartwig Amination: Enabling efficient C-N bond formation for the synthesis of aryl amines, a crucial step in pharmaceutical active ingredients.
• Suzuki-Miyaura Cross-Coupling: Facilitating the coupling of aryl/vinyl boronic acids with halides for biaryl synthesis in drug discovery and material science.
• Negishi and Related Cross-Couplings: Supporting C-C bond formation with organozinc reagents and other nucleophiles.
• Late-Stage Functionalization: Modifying complex molecules in pharmaceutical research with high selectivity and yield.
• Process Chemistry & Scale-Up: Serving as a robust catalyst for the pilot and commercial-scale manufacturing of fine chemicals and APIs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Academic & Industrial R&D: A key reagent for methodological development and exploring new catalytic transformations in laboratory settings.

Basic Information

Item	Details
Product Name	Ruphos Pd G3
CAS No.	1445085-77-7
Molecular Formula	C31H34Cl2N2PPd
Molecular Weight	663.89 g/mol
Synonyms	Chloro(2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); Dichloro[2-(2-aminoethyl)phenyl-C1,N][2-(dicyclohexylphosphino)-2',6'-di-i-propoxy-1,1'-biphenyl]palladium; RuPhos Palladacycle Gen 3; RuPhos Pd G3 Precatalyst; Pd-RuPhos G3; Palladium(II) RuPhos precatalyst; t-BuXPhos Pd G3 analog (RuPhos ligand); Buchwald Palladacycle RuPhos
EINECS	Contact for details

Quality Control

Our Ruphos Pd G3 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot undergoes comprehensive analytical characterization, including NMR, HPLC, and elemental analysis, to confirm identity and purity. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. This material is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange-brown solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Pd Content (ICP-MS)	15.5 - 16.5 %
Solubility	Soluble in common organic solvents (DCM, THF, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.