Description

3-(Fluoromethyl)Azetidine, Trifluoroacetic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine ring system functionalized with a fluoromethyl group. This compound is critical for medicinal chemists seeking to modulate the pharmacokinetic and metabolic properties of new drug candidates, particularly through the strategic introduction of fluorine. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs) across therapeutic areas such as oncology, neurology, and infectious diseases. The CAS number for this compound is 1443983-84-3.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those targeting protein-protein interactions or requiring improved metabolic stability.
• Fluorine Chemistry Research: Used in academic and industrial R&D to study the effects of fluorinated heterocycles on molecular properties like lipophilicity, bioavailability, and binding affinity.
• Agrochemical Development: Employed in the creation of new-generation pesticides and herbicides where the azetidine scaffold can contribute to unique modes of action.
• Ligand and Catalyst Design: Acts as a precursor for designing specialized ligands in asymmetric catalysis or for creating novel metal-organic frameworks (MOFs).
• PET (Positron Emission Tomography) Tracer Synthesis: The fluoromethyl group makes it a potential precursor for developing fluorine-18 labeled tracers for medical imaging.

Basic Information

Product Name	3-(Fluoromethyl)Azetidine, Trifluoroacetic Acid
CAS No.	1443983-84-3
Molecular Formula	C6H9F4NO2
Molecular Weight	203.14 g/mol
Synonyms	3-(Fluoromethyl)azetidine trifluoroacetate; Azetidine, 3-(fluoromethyl)-, trifluoroacetate (1:1); 3-Fluoromethylazetidine TFA salt; 1-Trifluoroacetyl-3-fluoromethylazetidine; 3-(Fluoromethyl)azetidinium trifluoroacetate; (Azetidin-3-yl)methanol, fluoro-, trifluoroacetate
EINECS	Contact for details

Quality Control

Every batch of 3-(Fluoromethyl)Azetidine, Trifluoroacetic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical R&D. Our quality assurance protocol includes identity confirmation, purity assay, and impurity profiling using advanced techniques like HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.