Description

(1S)-1-(3-Fluoro-4-Methylphenyl)Propylamine Hydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical synthesis. This compound matters as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other targeted therapies. Pharmaceutical R&D teams and fine chemical manufacturers need it for constructing complex molecular architectures where stereochemical purity is paramount for efficacy and safety.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel APIs, especially in neurological and psychiatric drug candidates.
• Asymmetric Synthesis: Used as a building block in catalytic asymmetric reactions to introduce stereocenters in complex organic molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Ligand and Catalyst Preparation: Potential precursor for chiral ligands or organocatalysts used in enantioselective transformations.
• Reference Standard: Suitable for use as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	(1S)-1-(3-Fluoro-4-Methylphenyl)Propylamine Hydrochloride
CAS No.	1443931-90-5
Molecular Formula	C10H15ClFN
Molecular Weight	203.68 g/mol
Synonyms	(S)-1-(3-Fluoro-4-methylphenyl)propan-1-amine hydrochloride; (1S)-1-(3-Fluoro-4-methylphenyl)-1-propylamine hydrochloride; (S)-1-(3-Fluoro-4-methylphenyl)propylamine HCl; (S)-3-Fluoro-4-methyl-α-propylbenzylamine hydrochloride; (S)-α-Methyl-3-fluoro-4-methylphenethylamine hydrochloride; Benzenemethanamine, 3-fluoro-4-methyl-α-propyl-, (αS)-, hydrochloride; 1443931-90-5
EINECS	Contact for details

Quality Control

Our (1S)-1-(3-Fluoro-4-Methylphenyl)Propylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.