Description

1H-Inden-1-Amine,5-Bromo-2,3-Dihydro-,Hydrochloride(1:1),(1R)- is a high-purity chiral amine derivative, specifically the (1R)-enantiomer of a brominated indane scaffold, offered as a stable hydrochloride salt. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile building block for medicinal chemistry research and development. It is essential for organizations engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas requiring complex, stereochemically defined molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a precision building block for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Asymmetric Synthesis: Employed in chiral pool synthesis and as a starting material for catalysts or ligands due to its defined (1R) stereochemistry.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways.
• Process Chemistry Development: Serves as a reference standard and starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic & Institutional Research: Used in universities and research institutes for advanced organic synthesis projects and methodological studies.

Basic Information

Product Name	1H-Inden-1-Amine,5-Bromo-2,3-Dihydro-,Hydrochloride(1:1),(1R)-
CAS No.	1443238-61-6
Molecular Formula	C9H9BrClN
Molecular Weight	246.53 g/mol
Synonyms	(1R)-5-Bromo-2,3-dihydro-1H-inden-1-amine hydrochloride; (1R)-5-Bromoindan-1-amine hydrochloride; (R)-5-Bromo-2,3-dihydro-1H-inden-1-amine hydrochloride; 5-Bromo-(1R)-1-aminoindane hydrochloride; (R)-1-Amino-5-bromoindane HCl; 1443238-61-6; (1R)-1-Amino-5-bromo-2,3-dihydro-1H-indene hydrochloride
EINECS	Contact for details

Quality Control

Our 1H-Inden-1-Amine,5-Bromo-2,3-Dihydro-,Hydrochloride(1:1),(1R)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to relevant quality management standards to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (1R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.