Description

3-Bromo-2-Hydroxy-5-[(Trifluoromethyl)Sulphonyl]Nitrobenzene, also known as 3-Bromo-4-Hydroxy-5-Nitrophenyl Trifluoromethyl Sulphone, is a high-value, multi-functional aromatic intermediate characterized by its distinct bromo, hydroxy, nitro, and trifluoromethylsulphonyl substituents. This compound is engineered to serve as a critical building block in advanced synthetic chemistry, offering unique reactivity for constructing complex molecular architectures. It is primarily sought after by research and development teams and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and functional materials.

Application

This versatile intermediate is designed for sophisticated synthesis pathways where its specific functional groups enable precise chemical transformations.

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethylsulphonyl group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating complex ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups and potential for cross-linking.
• Dye and Pigment Intermediate: Acts as a precursor for synthesizing specialized dyes and pigments where nitro and sulphonyl groups contribute to color fastness and specific spectral properties.
• Custom Synthesis and Contract Manufacturing: A valuable substrate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global fine chemical market.

Basic Information

Product Name	3-Bromo-2-Hydroxy-5-[(Trifluoromethyl)Sulphonyl]Nitrobenzene / 3-Bromo-4-Hydroxy-5-Nitrophenyl Trifluoromethyl Sulphone
CAS No.	1440535-14-7
Molecular Formula	C7H3BrF3NO5S
Molecular Weight	349.07 g/mol
Synonyms	3-Bromo-4-hydroxy-5-nitrobenzenesulfonyl fluoride, trifluoromethylated; 3-Bromo-2-hydroxy-5-nitro-alpha,alpha,α-trifluorobenzenemethanesulfonic acid; 3-Bromo-4-hydroxy-5-nitrophenyl trifluoromethyl sulfone; 5-[(Trifluoromethyl)sulfonyl]-3-bromo-2-nitrophenol; Benzenesulfonyl fluoride, 3-bromo-4-hydroxy-5-nitro-, trifluoromethylated; 3-Bromo-2-nitrophenyl trifluoromethyl sulfone, 4-hydroxy-; CAS 1440535-14-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and purity suitable for research and scale-up. Each lot is analyzed using modern analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with REACH and other relevant global regulatory frameworks for chemical substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.