Description

(2-Methyl-5,6,7,8-Tetrahydro-Quinazolin-6-Yl)-Carbamic Acid tert-Butyl Ester CAS NO 1440526-43-1 is a high-purity, protected amine derivative belonging to the quinazoline class of heterocyclic compounds. This advanced pharmaceutical intermediate is critical for the synthesis of complex molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in route scouting and scale-up synthesis for the manufacturing of complex target molecules.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.
• Academic Research: Employed in university and institutional labs for the study of heterocyclic chemistry and new synthetic methodologies.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) protecting group allows for selective deprotection in multi-step synthesis sequences.

Basic Information

Product Name	(2-Methyl-5,6,7,8-Tetrahydro-Quinazolin-6-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	1440526-43-1
Molecular Formula	C₁₄H₂₁N₃O₂
Molecular Weight	263.34 g/mol
Synonyms	tert-Butyl (2-methyl-5,6,7,8-tetrahydroquinazolin-6-yl)carbamate; 6-((tert-Butoxycarbonyl)amino)-2-methyl-5,6,7,8-tetrahydroquinazoline; Boc-6-amino-2-methyl-5,6,7,8-tetrahydroquinazoline; N-Boc-2-methyl-5,6,7,8-tetrahydroquinazolin-6-amine; (2-Methyl-5,6,7,8-tetrahydroquinazolin-6-yl)carbamic acid 1,1-dimethylethyl ester; 1440526-43-1; 2-Methyl-5,6,7,8-tetrahydroquinazolin-6-yl-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (2-Methyl-5,6,7,8-Tetrahydro-Quinazolin-6-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications, and our quality commitment ensures reliable supply for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.