Description

1-[4-(Trifluoromethyl)Benzyl]Cyclobutylmethanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutyl and a trifluoromethylbenzyl motif. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting CNS disorders and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable, high-quality building block for complex synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its unique cyclobutyl and fluorine-containing aromatic structure.
• Preclinical Drug Development: Serves as a critical precursor for producing candidate compounds for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) engaged in the custom synthesis of complex organic molecules for clients.
• Agrochemical Research: Potential intermediate in the development of new agrochemicals, leveraging the physicochemical properties imparted by the trifluoromethyl group.

Basic Information

Product Name	1-[4-(Trifluoromethyl)Benzyl]Cyclobutylmethanamine Hydrochloride
CAS No.	1439903-10-2
Molecular Formula	C13H17ClF3N
Molecular Weight	279.73 g/mol
Synonyms	1-[(4-(Trifluoromethyl)phenyl)methyl]cyclobutanemethanamine hydrochloride; Cyclobutanemethanamine, 1-[[4-(trifluoromethyl)phenyl]methyl]-, hydrochloride; 1-((4-(Trifluoromethyl)benzyl)cyclobutyl)methanamine HCl; 1-[4-(Trifluoromethyl)benzyl]cyclobutylmethylamine hydrochloride; α-(4-(Trifluoromethyl)benzyl)cyclobutanemethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethyl)Benzyl]Cyclobutylmethanamine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.