Description

6'-Fluoro-2',4'-Dihydro-1'H-Spiro[Piperidine-4,3'-Quinoline]-2'-One Hydrochlorid is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and quinoline-based molecular architecture. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and other therapeutic areas. It is an essential building block for pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel pharmacophores.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening in drug discovery.
• Targeted Drug Synthesis: Employed in the research and synthesis of potential therapeutics for neurological disorders, psychiatric conditions, and other disease areas.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays and target validation studies.

Basic Information

Product Name	6'-Fluoro-2',4'-Dihydro-1'H-Spiro[Piperidine-4,3'-Quinoline]-2'-One Hydrochlorid
CAS No.	1439902-51-8
Molecular Formula	C17H20FN2O • HCl
Molecular Weight	324.81 g/mol (Free base: 288.36 g/mol)
Synonyms	6'-Fluoro-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline]-2'-one hydrochloride; 6-Fluoro-2,4-dihydrospiro[piperidine-4,3'-quinoline]-2'(1'H)-one hydrochloride; Spiro[piperidine-4,3'-quinoline]-2'-one, 6'-fluoro-2',4'-dihydro-1'H-, hydrochloride; 1439902-51-8; 6'-Fluoro-1'H-spiro[piperidine-4,3'-quinoline]-2',4'(2'H)-dione hydrochloride (tautomeric form); 6-Fluoro-spiro[piperidine-4,3'-quinoline]-2'(1'H)-one hydrochloride.
EINECS	Contact for details

Quality Control

Our 6'-Fluoro-2',4'-Dihydro-1'H-Spiro[Piperidine-4,3'-Quinoline]-2'-One Hydrochlorid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for trace solvents, related substances, and assay results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable material for critical research and development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual unknown: ≤ 0.5%; Total: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.