Description

2-Oxo-1-[(Tetrahydro-2H-Pyran-4-Yl)Methyl]-1,2-Dihydropyrimidine-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug molecules, particularly for central nervous system (CNS) and antiviral targets.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Process Chemistry Development: Employed in route scouting and optimization for scalable API manufacturing processes.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and proprietary compounds.
• Bioconjugation & Probe Development: Potential use in creating chemical probes for biochemical and diagnostic applications due to its functionalizable carboxylic acid group.

Basic Information

Product Name	2-Oxo-1-[(Tetrahydro-2H-Pyran-4-Yl)Methyl]-1,2-Dihydropyrimidine-5-Carboxylic Acid
CAS No.	1439902-37-0
Molecular Formula	C₁₂H₁₆N₂O₄
Molecular Weight	252.27 g/mol
Synonyms	1,2-Dihydropyrimidine-5-carboxylic acid, 2-oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-; 1-((Tetrahydro-2H-pyran-4-yl)methyl)-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid; 2-Oxo-1-(tetrahydropyran-4-ylmethyl)-1,2-dihydropyrimidine-5-carboxylic acid; THP-Methyl Dihydropyrimidine Carboxylic Acid; CAS 1439902-37-0
EINECS	Contact for details

Quality Control

Our 2-Oxo-1-[(Tetrahydro-2H-Pyran-4-Yl)Methyl]-1,2-Dihydropyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided to ensure compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is stable under these conditions but should be kept away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.