Description

1-(4-(Trifluoromethyl)Phenyl)Cyclobutanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its cyclobutane and trifluoromethylphenyl structural motifs. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. Pharmaceutical R&D laboratories and fine chemical manufacturers need it to develop next-generation therapeutic candidates, leveraging its unique scaffold to modulate drug potency, selectivity, and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry programs.
• CNS Drug Discovery: Used in research and development of therapeutics targeting neurological disorders, where the cyclobutylamine core is a valuable pharmacophore.
• Oncology Research: Employed as a building block for creating potential kinase inhibitors and other targeted cancer therapies.
• Agrochemical Synthesis: Functions as an intermediate in the development of advanced crop protection agents with enhanced efficacy.
• Material Science Research: Investigated for incorporation into specialty polymers and advanced organic materials due to its rigid cyclic structure.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	1-(4-(Trifluoromethyl)Phenyl)Cyclobutanamine Hydrochloride
CAS No.	1439902-32-5
Molecular Formula	C11H13F3N·HCl
Molecular Weight	243.68 g/mol (Free base: 207.22 g/mol)
Synonyms	1-[4-(Trifluoromethyl)phenyl]cyclobutan-1-amine hydrochloride; 4-(Trifluoromethyl)benzenecyclobutanamine hydrochloride; 1-(4-Trifluoromethylphenyl)cyclobutanamine HCl; 1-(p-Trifluoromethylphenyl)cyclobutanamine hydrochloride; 4-(Aminocyclobutyl)benzotrifluoride hydrochloride; Cyclobutanamine, 1-[4-(trifluoromethyl)phenyl]-, hydrochloride (1:1); CAS 1439902-32-5
EINECS	Contact for details

Quality Control

Our 1-(4-(Trifluoromethyl)Phenyl)Cyclobutanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.