Description

8'-Fluoro-2',4'-Dihydro-1'H-Spiro[Oxane-4,3'-Quinoline] is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic quinoline scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system and metabolic disorders. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to build complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those with spirocyclic or fused heterocyclic structures.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to explore new chemical space for drug discovery programs.
• Chemical Biology Probes: Serves as a core scaffold for developing molecular probes to study biological pathways and enzyme functions.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient production of complex target molecules.
• Fine Chemical Synthesis: Utilized as a specialized reagent for constructing complex organic molecules in custom synthesis and contract manufacturing.

Basic Information

Product Name	8'-Fluoro-2',4'-Dihydro-1'H-Spiro[Oxane-4,3'-Quinoline]
CAS No.	1439902-17-6
Molecular Formula	C13H14FNO
Molecular Weight	219.26 g/mol
Synonyms	8'-Fluoro-2',4'-dihydro-1'H-spiro[oxane-4,3'-quinoline]; 1'H-Spiro[oxane-4,3'-quinoline], 8'-fluoro-2',4'-dihydro-; Spiro[oxane-4,3'-quinoline], 8'-fluoro-2',4'-dihydro-1'H-; 8-Fluoro-2,4-dihydro-1H-spiro[oxane-4,3-quinoline]; 1439902-17-6; 8'-Fluoro-spiro[oxane-4,3'-quinoline]; Fluorinated spirocyclic quinoline
EINECS	Contact for details

Quality Control

Our 8'-Fluoro-2',4'-Dihydro-1'H-Spiro[Oxane-4,3'-Quinoline] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.