Description

(2S)-2-Ethylbutyl 2-(((4-Nitrophenoxy)(Phenoxy)Phosphoryl)Amino)Propanoate is a specialized organophosphorus compound featuring a chiral center and a nitrophenoxy group, making it a valuable intermediate for advanced chemical synthesis. Its molecular architecture is designed to act as a key building block or a reactive moiety in the development of complex molecules, particularly in pharmaceutical and agrochemical research. This high-purity intermediate is essential for R&D chemists and process development scientists working on novel active ingredients, chiral catalysts, or functional materials where precise stereochemistry and reactivity are critical.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for compounds targeting neurological or metabolic pathways.
• Agrochemical Synthesis: Used in the development of next-generation pesticides and herbicides, where its phosphoramidate structure can contribute to novel modes of action.
• Chemical Biology Probe Development: Acts as a precursor for creating activity-based probes or affinity labels to study enzyme function, especially serine hydrolases or related protein families.
• Polymer Science: Can be utilized as a functional monomer or cross-linking agent to introduce specific phosphorus-containing groups into polymer backbones for specialty materials.
• Catalyst Ligand Precursor: Provides a framework for synthesizing novel chiral ligands used in asymmetric catalysis for the production of enantiomerically pure compounds.
• Peptidomimetic Research: Incorporated into peptide analogs to enhance stability, membrane permeability, or to introduce specific bioisosteric properties.

Basic Information

Product Name	(2S)-2-Ethylbutyl 2-(((4-Nitrophenoxy)(Phenoxy)Phosphoryl)Amino)Propanoate
CAS No.	1439900-56-7
Molecular Formula	C21H27N2O7P
Molecular Weight	450.42 g/mol
Synonyms	L-Alanine, N-[(4-nitrophenoxy)phenoxyphosphinyl]-, 2-ethylbutyl ester, (2S)-; (S)-2-Ethylbutyl 2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate; Propanoic acid, 2-[[(4-nitrophenoxy)phenoxyphosphinyl]amino]-, 2-ethylbutyl ester, (2S)-; Phosphoramidic acid, N-(1-carboxyethyl)-, 2-ethylbutyl 4-nitrophenyl phenyl ester, (S)-; O-(4-Nitrophenyl) O-phenyl N-[(1S)-1-(2-ethylbutoxycarbonyl)ethyl]phosphoramidate; Chiral Phosphoramidate Ester; 4-Nitrophenyl Phenyl (S)-1-(2-Ethylbutoxycarbonyl)ethylphosphoramidate
EINECS	Contact for details

Quality Control

Our production of (2S)-2-Ethylbutyl 2-(((4-Nitrophenoxy)(Phenoxy)Phosphoryl)Amino)Propanoate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, enantiomeric excess, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.