Description

n-(4-Bromo-2-Fluorophenyl)-7-Methoxy-6-(3-(Tetrahydro-2H-[1,4]Dioxino[2,3-C]Pyrrol-6(3H)-Yl)Propoxy)Quinazolin-4-Amine is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of targeted therapeutic agents. This compound is critical for research and development in medicinal chemistry, particularly for programs focused on kinase inhibition. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel, small-molecule drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel quinazoline-based kinase inhibitors for oncology and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes during drug discovery.
• Preclinical Development: Serves as a critical material for producing Active Pharmaceutical Ingredients (APIs) for toxicology and pharmacology studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules.
• Academic Research: Employed in university and institutional labs for chemical biology studies and the development of new synthetic methodologies.

Basic Information

Product Name	n-(4-Bromo-2-Fluorophenyl)-7-Methoxy-6-(3-(Tetrahydro-2H-[1,4]Dioxino[2,3-C]Pyrrol-6(3H)-Yl)Propoxy)Quinazolin-4-Amine
CAS No.	1438072-35-5
Molecular Formula	C24H26BrFN4O4
Molecular Weight	533.39 g/mol
Synonyms	4-((4-Bromo-2-fluorophenyl)amino)-7-methoxy-6-(3-(1,4-dioxa-7-azaspiro[4.4]nonan-7-yl)propoxy)quinazoline; 1438072-35-5; 4-[(4-Bromo-2-fluorophenyl)amino]-7-methoxy-6-[3-(1,4-dioxa-7-azaspiro[4.4]nonan-7-yl)propoxy]quinazoline; 6-[3-(1,4-Dioxa-7-azaspiro[4.4]nonan-7-yl)propoxy]-4-[(4-bromo-2-fluorophenyl)amino]-7-methoxyquinazoline; UNII-3U7Z7KQN0B; 3U7Z7KQN0B; BDBM50382878; AKOS025310991
EINECS	Contact for details

Quality Control

Our n-(4-Bromo-2-Fluorophenyl)-7-Methoxy-6-(3-(Tetrahydro-2H-[1,4]Dioxino[2,3-C]Pyrrol-6(3H)-Yl)Propoxy)Quinazolin-4-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or GMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.