Description

tert-Butyl 2-oxo-5-azaspiro[3.4]octane-5-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries to create new therapeutic candidates, particularly in central nervous system (CNS) and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those containing spirocyclic and proline-like motifs.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The 2-oxo-5-azaspiro structure is valuable for designing inhibitors of various enzymes, including kinases and proteases.
• Peptidomimetic Synthesis: Acts as a constrained, non-natural amino acid analog for creating stable peptide mimics with enhanced pharmacological properties.
• Chemical Biology Probes: Employed in the development of tool compounds for investigating biological pathways and target validation.
• Process Chemistry & Scale-Up: Serves as a critical intermediate for optimizing synthetic routes during the transition from laboratory to pilot and commercial-scale API manufacturing.

Basic Information

Product Name	tert-Butyl 2-oxo-5-azaspiro[3.4]octane-5-carboxylate
CAS No.	1434141-78-2
Molecular Formula	C12H19NO3
Molecular Weight	225.28 g/mol
Synonyms	5-azaspiro[3.4]octane-5-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester; 2-Oxo-5-azaspiro[3.4]octane-5-carboxylic acid tert-butyl ester; tert-Butyl 2-oxo-5-azaspiro[3.4]octane-5-carboxylate; 5-Boc-2-oxo-5-azaspiro[3.4]octane; Boc-5-azaspiro[3.4]octan-2-one-5-carboxylate; 1434141-78-2; Spirocyclic proline derivative tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-oxo-5-azaspiro[3.4]octane-5-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.