Description

(3S,4S)-3-Fluoropiperidin-4-Ol Hydrochloride is a high-purity chiral piperidine derivative, serving as a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined fluorine-bearing scaffold essential for modulating the biological activity and metabolic stability of drug candidates. This advanced intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas such as central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms for optimizing drug potency and pharmacokinetic properties.
• Preclinical Candidate Synthesis: Employed in the scalable synthesis of lead compounds and preclinical candidates.
• Protease & Kinase Inhibitor Development: Serves as a core structural motif in the design of targeted inhibitors for various disease pathways.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological mechanisms and target validation.
• Process Chemistry & Route Scouting: Acts as a starting material for developing efficient, asymmetric synthetic routes for complex molecules.

Basic Information

Product Name	(3S,4S)-3-Fluoropiperidin-4-Ol Hydrochloride
CAS No.	1434126-98-3
Molecular Formula	C5H11ClFNO
Molecular Weight	155.60 g/mol (Free base: 119.15 g/mol)
Synonyms	(3S,4S)-3-Fluoro-4-hydroxypiperidine hydrochloride; (3S,4S)-3-Fluoro-4-piperidinol hydrochloride; (3S,4S)-3-Fluoro-4-hydroxy-piperidine HCl; (3S,4S)-3-Fluoropiperidin-4-ol HCl; 4-Piperidinol, 3-fluoro-, (3S,4S)-, hydrochloride; (3S,4S)-3-Fluoro-4-piperidinol HCl salt; 3-Fluoro-4-hydroxypiperidine hydrochloride (stereoisomer)
EINECS	Contact for details

Quality Control

Our (3S,4S)-3-Fluoropiperidin-4-Ol Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 103.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.