Description

6-Bromo-5-Fluoroisoquinoline is a high-value halogenated isoquinoline derivative, serving as a critical building block in modern synthetic organic chemistry. Its molecular structure, featuring both bromine and fluorine substituents, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in drug discovery, medicinal chemistry, and the synthesis of advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting kinases and other biologically relevant receptors.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization to introduce halogen atoms for modulating potency, metabolic stability, and lipophilicity.
• Agrochemical Development: Serves as a building block for creating novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated isoquinoline scaffold.
• Material Science: Employed in the research and development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form new carbon-carbon bonds.
• Fluorine Chemistry Library Synthesis: A valuable reagent for constructing diverse compound libraries focused on fluorine-containing molecules for high-throughput screening.

Basic Information

Product Name	6-Bromo-5-Fluoroisoquinoline
CAS No.	1432754-56-7
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	5-Fluoro-6-bromoisoquinoline; Isoquinoline, 6-bromo-5-fluoro-; 6-Bromo-5-fluoro-isoquinoline; 1432754-56-7; 5-Fluoro-6-bromo-isoquinoline; 6-Bromo-5-fluoroisoquinoline; 6-Br-5-F-isoquinoline
EINECS	Contact for details

Quality Control

Our 6-Bromo-5-Fluoroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.