Description

8-Bromo-2-Chloro-5-Fluoroquinoline is a high-purity, multi-halogenated quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinolone-based antibiotics, anticancer agents, and other therapeutic compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science: Serves as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and other electronic materials due to its electron-deficient quinoline core.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce complex functionalities.
• Dye and Pigment Industry: Acts as an intermediate for synthesizing specialized dyes and pigments with specific light-fastness and color properties.
• Academic & Contract Research: A valuable reagent for methodological studies and library synthesis in medicinal and synthetic chemistry programs.

Basic Information

Product Name	8-Bromo-2-Chloro-5-Fluoroquinoline
CAS No.	1432323-01-7
Molecular Formula	C9H4BrClFN
Molecular Weight	260.49 g/mol
Synonyms	8-Bromo-2-chloro-5-fluoroquinoline; 2-Chloro-8-bromo-5-fluoroquinoline; 5-Fluoro-8-bromo-2-chloroquinoline; Quinoline, 8-bromo-2-chloro-5-fluoro-; 1432323-01-7; 8-Br-2-Cl-5-F-quinoline
EINECS	Contact for details

Quality Control

Our 8-Bromo-2-Chloro-5-Fluoroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.