Description

8-Bromo-2-fluoro-1,5-naphthyridine is a high-purity, halogenated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by research scientists and process chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and drug discovery programs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its halogenated naphthyridine core.
• Material Science Precursor: Serves as a starting material for creating specialized ligands, organic semiconductors, and photoactive compounds.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create diverse biaryl structures.
• Nucleophilic Aromatic Substitution: The fluoro group is reactive in nucleophilic aromatic substitution (SNAr), allowing for further functionalization of the naphthyridine ring system.

Basic Information

Product Name	8-Bromo-2-fluoro-1,5-naphthyridine
CAS No.	1432322-85-4
Molecular Formula	C8H4BrFN2
Molecular Weight	227.04 g/mol
Synonyms	8-Bromo-2-fluoro-1,5-naphthyridine; 2-Fluoro-8-bromo-1,5-naphthyridine; 1,5-Naphthyridine, 8-bromo-2-fluoro-; 8-Bromo-2-fluoro-[1,5]naphthyridine; 1432322-85-4; 8-Br-2-F-1,5-Naphthyridine
EINECS	Contact for details

Quality Control

Our 8-Bromo-2-fluoro-1,5-naphthyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.