Description

5-[4-[3-[(4-Acetyl-1-Piperazinyl)Carbonyl]Phenyl]-6-Quinazolinyl]-2-Methoxy-3-Pyridinecarbonitrile is a high-purity, advanced pharmaceutical intermediate designed for research and development in targeted therapies. This compound is critical for medicinal chemists and process development scientists working on novel kinase inhibitors and other small molecule therapeutics. Its primary value lies in enabling the synthesis of complex drug candidates, serving the global pharmaceutical, biotechnology, and advanced contract research organization (CRO) sectors.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of investigational new drugs (INDs) and new chemical entities (NCEs), particularly in oncology research.
• Kinase Inhibitor Development: Core scaffold for the research and development of potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to improve drug efficacy and safety profiles.
• Process Chemistry & Scale-Up: Serves as a critical intermediate for process development, route scouting, and cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Assay Development: Utilized as a reference standard or probe compound in high-throughput screening (HTS) and biochemical assays.
• Academic & Institutional Research: Supports basic and applied research in chemical biology and drug discovery at universities and research institutes.

Basic Information

Product Name	5-[4-[3-[(4-Acetyl-1-Piperazinyl)Carbonyl]Phenyl]-6-Quinazolinyl]-2-Methoxy-3-Pyridinecarbonitrile
CAS No.	1431540-99-6
Molecular Formula	C28H24N6O3
Molecular Weight	492.53 g/mol
Synonyms	5-[4-[3-[(4-Acetylpiperazin-1-yl)carbonyl]phenyl]quinazolin-6-yl]-2-methoxynicotinonitrile; 2-Methoxy-5-[4-[3-[(4-acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-3-pyridinecarbonitrile; UNII-7K8I1W6J5F; 7K8I1W6J5F; 5-{4-[3-(4-Acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile; 5-(4-(3-(4-Acetylpiperazine-1-carbonyl)phenyl)quinazolin-6-yl)-2-methoxynicotinonitrile
EINECS	Contact for details

Quality Control

Our 5-[4-[3-[(4-Acetyl-1-Piperazinyl)Carbonyl]Phenyl]-6-Quinazolinyl]-2-Methoxy-3-Pyridinecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.