Description

4-Amino-1-Boc-7-Bromo-3,4-Dihydro-2H-Quinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and protected amine structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel quinoline-based active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under cGMP conditions for clinical trial material production.
• Proteolysis Targeting Chimera (PROTAC) Synthesis: Utilized in the construction of linker-warhead components for targeted protein degradation platforms.
• Chemical Biology Probes: Acts as a precursor for developing labeled compounds and molecular probes used in biochemical assays and target identification.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and process development.

Basic Information

Product Name	4-Amino-1-Boc-7-Bromo-3,4-Dihydro-2H-Quinoline Hydrochloride
CAS No.	1430839-89-6
Molecular Formula	C₁₄H₁₈BrClN₂O₂
Molecular Weight	361.66 g/mol
Synonyms	1-Boc-7-Bromo-4-amino-3,4-dihydro-2H-quinoline Hydrochloride; 7-Bromo-4-amino-1-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinoline Hydrochloride; tert-Butyl 7-bromo-4-amino-3,4-dihydro-2H-quinoline-1-carboxylate Hydrochloride; 4-Amino-7-bromo-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester hydrochloride; 4-Amino-1-Boc-7-bromo-1,2,3,4-tetrahydroquinoline HCl; 1-N-Boc-7-bromo-4-amino-1,2,3,4-tetrahydroquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Amino-1-Boc-7-Bromo-3,4-Dihydro-2H-Quinoline Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our analytical methods are validated to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.