Description

5-Methoxy-2-Nitro-4-[[Tris(1-Methylethyl)Silyl]Oxy]Benzoic Acid is a sophisticated, high-purity synthetic intermediate featuring a silyl-protected phenolic group, which is critical for controlled deprotection in multi-step organic synthesis. Its core value lies in enabling precise chemical transformations, offering researchers and manufacturers a reliable building block for constructing complex molecular architectures. This compound is primarily needed by pharmaceutical R&D teams and fine chemical producers engaged in developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key protected precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, where the nitro and silyloxy groups are leveraged for further functionalization.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a building block for electron-transport or host materials in the production of high-performance display and lighting technologies.
• Ligand and Catalyst Development: Employed in academic and industrial research to create novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring high-purity, specialized intermediates.
• Polymer Chemistry: Potential monomer or modifier for creating specialty polymers with tailored thermal or optical properties.

Basic Information

Product Name	5-Methoxy-2-Nitro-4-[[Tris(1-Methylethyl)Silyl]Oxy]Benzoic Acid
CAS No.	1430738-03-6
Molecular Formula	C17H27NO6Si
Molecular Weight	369.49 g/mol
Synonyms	4-(Triisopropylsilyloxy)-5-methoxy-2-nitrobenzoic acid; 2-Nitro-5-methoxy-4-(triisopropylsilyloxy)benzoic acid; Benzoic acid, 5-methoxy-2-nitro-4-[(triisopropylsilyl)oxy]-; TIPS-protected nitro-methoxybenzoic acid; 4-(TIPS-O)-5-MeO-2-NO2-Benzoic Acid; CAS 1430738-03-6
EINECS	Contact for details

Quality Control

Our 5-Methoxy-2-Nitro-4-[[Tris(1-Methylethyl)Silyl]Oxy]Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.