Description

(R)-3-(Trifluoromethyl)Morpholine Hydrochloride is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical and agrochemical research. Its value lies in the unique combination of the morpholine scaffold and the trifluoromethyl group, which are critical for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel drug candidates, especially in neuroscience and oncology.
• Agrochemical Research: Building block for creating advanced pesticides and herbicides with improved efficacy and selectivity.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions.
• Medicinal Chemistry: Core structure for SAR (Structure-Activity Relationship) studies to optimize potency, metabolic stability, and bioavailability.
• Process Chemistry: Serves as a starting material for scaling up the production of advanced intermediates under GMP conditions.
• Chemical Biology: Probe molecule for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	(R)-3-(Trifluoromethyl)Morpholine Hydrochloride
CAS No.	1430086-53-5
Molecular Formula	C5H9ClF3NO
Molecular Weight	191.58 g/mol
Synonyms	(R)-3-(Trifluoromethyl)morpholine hydrochloride; (R)-3-(Trifluoromethyl)morpholine HCl; (3R)-3-(Trifluoromethyl)morpholine hydrochloride; Morpholine, 3-(trifluoromethyl)-, hydrochloride, (3R)-; (R)-3-Trifluoromethylmorpholine hydrochloride; (R)-3-CF3-Morpholine HCl; (R)-TFM-Morpholine HCl
EINECS	Contact for details

Quality Control

Our (R)-3-(Trifluoromethyl)Morpholine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. We provide comprehensive analytical data including chiral purity (enantiomeric excess) and impurity profiling by advanced chromatographic techniques. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and related substances are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% e.e.
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.