Description

5'‐Bromo‐1',2'‐Dihydrospiro[Cyclopentane‐1,3'‐Pyrrolo[2,3‐B]Pyridine]‐2'‐One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused heterocyclic structure. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily needed by R&D and process development teams in the pharmaceutical, biotechnology, and fine chemical industries for the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new drug molecules, particularly in oncology and central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probe Synthesis: Employed in the creation of specialized molecular probes for studying biological pathways and target validation.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.
• Academic Research: Used in university and institutional laboratories for advanced organic synthesis methodology and novel heterocyclic chemistry research.

Basic Information

Product Name	5'‐Bromo‐1',2'‐Dihydrospiro[Cyclopentane‐1,3'‐Pyrrolo[2,3‐B]Pyridine]‐2'‐One
CAS No.	1428799-34-1
Molecular Formula	C12H11BrN2O
Molecular Weight	279.13 g/mol
Synonyms	5'-Bromo-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one; 5'-Bromospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; 1428799-34-1; Spiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridine]-2'-one, 5'-bromo-1',2'-dihydro-; 5'-Bromo-1',2'-dihydro-2'H-spiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one
EINECS	Contact for details

Quality Control

Our 5'‐Bromo‐1',2'‐Dihydrospiro[Cyclopentane‐1,3'‐Pyrrolo[2,3‐B]Pyridine]‐2'‐One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.