Description

1',2'-Dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused heterocyclic structure. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: The pyrrolopyridine core is a privileged structure in the design of potent and selective kinase inhibitors for oncology applications.
• CNS Drug Discovery: Employed in the research and development of therapeutics for neurological and psychiatric disorders.
• Chemical Biology Probes: Serves as a starting material for creating tool compounds to study biological processes and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	1',2'-Dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one
CAS No.	1428799-33-0
Molecular Formula	C12H14N2O
Molecular Weight	202.25 g/mol
Synonyms	Spiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one, 1',2'-Dihydro-; 1'H-Spiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one; 1428799-33-0; Spirocyclic pyrrolopyridinone; Pyrrolo[2,3-b]pyridine-2-one, 1,2-dihydrospiro[cyclopentane-1,3']-
EINECS	Contact for details

Quality Control

Our 1',2'-Dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for advanced pharmaceutical intermediates to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.