Description

5'-Bromo-1',2'-Dihydrospiro[Cyclobutane-1,3'-Pyrrolo[2,3-B]Pyridine]-2'-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused heterocyclic structure. This compound matters as a critical building block for medicinal chemistry research, enabling the synthesis of novel drug candidates with potential activity in central nervous system and oncology targets. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses due to its reactive bromo and carbonyl functional groups.
• Drug Discovery Programs: Particularly relevant for programs targeting kinase inhibitors or modulators of neurological pathways, given its pyrrolopyridine core.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	5'-Bromo-1',2'-Dihydrospiro[Cyclobutane-1,3'-Pyrrolo[2,3-B]Pyridine]-2'-One
CAS No.	1428799-32-9
Molecular Formula	C11H11BrN2O
Molecular Weight	267.12 g/mol
Synonyms	5'-Bromo-1',2'-dihydrospiro[cyclobutane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one; 5'-Bromospiro[cyclobutane-1,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; Spiro[cyclobutane-1,3'-pyrrolo[2,3-b]pyridine]-2'-one, 5'-bromo-1',2'-dihydro-; 1428799-32-9; 5-Bromo-1,2-dihydrospiro[cyclobutane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one
EINECS	Contact for details

Quality Control

Our 5'-Bromo-1',2'-Dihydrospiro[Cyclobutane-1,3'-Pyrrolo[2,3-B]Pyridine]-2'-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.