Description

(R)-(Fluoromethyl)-Benzenemethanamine Hydrochloride (Wxfc0134) is a high-purity chiral amine hydrochloride salt, a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined, fluorinated scaffold essential for developing targeted bioactive molecules. This compound is primarily needed by research and development chemists and process development teams in the pharmaceutical and agrochemical industries for creating new drug candidates and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the specific stereochemistry can influence biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity in complex reactions.
• Peptidomimetics Research: Incorporated into peptide analogs to enhance metabolic stability, membrane permeability, and binding affinity through fluorination.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and receptor interactions due to its fluorine atom, which can act as an isostere or be used in 19F NMR studies.
• Material Science: Potential monomer or modifier in the synthesis of specialty polymers with unique optical or electronic properties.

Basic Information

Product Name	(R)-(Fluoromethyl)-Benzenemethanamine Hydrochloride (Wxfc0134)
CAS No.	1428333-84-9
Molecular Formula	C9H11ClFN
Molecular Weight	187.64 g/mol
Synonyms	(R)-1-(Fluoromethyl)benzylamine hydrochloride; (R)-α-(Fluoromethyl)benzylamine hydrochloride; (R)-(1-Fluoroethyl)benzylamine hydrochloride (common misnomer); (R)-1-Phenylethylamine, α-fluoro-, hydrochloride; Benzenemethanamine, (αR)-α-(fluoromethyl)-, hydrochloride; WXFC0134; (R)-FMBHA·HCl
EINECS	Contact for details

Quality Control

Every batch of (R)-(Fluoromethyl)-Benzenemethanamine Hydrochloride is produced and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for research and cGMP starting material applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/Chiral HPLC), and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.