Description

(R)-n-(1-(Naphthalen-1-Yl)Ethyl)-3-(4-(Trifluoromethyl)Phenyl)Propan-1-Amine Hydrochloride CAS NO 1428118-39-1 is a high-purity chiral amine hydrochloride salt, characterized by its naphthalene and trifluoromethylphenyl functional groups. This compound is a critical pharmaceutical intermediate valued for its role in the synthesis of active pharmaceutical ingredients (APIs) and advanced organic molecules. It is primarily required by research institutions, pharmaceutical R&D labs, and fine chemical manufacturers engaged in developing new therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective chemical reactions to produce enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Production: Employed in the manufacture of advanced agrochemicals, specialty polymers, and complex organic materials.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(R)-n-(1-(Naphthalen-1-Yl)Ethyl)-3-(4-(Trifluoromethyl)Phenyl)Propan-1-Amine Hydrochloride
CAS No.	1428118-39-1
Molecular Formula	C22H22F3N•HCl
Molecular Weight	393.88 g/mol (Free base: 357.42 g/mol)
Synonyms	(R)-1-(1-Naphthyl)-N-[3-[4-(trifluoromethyl)phenyl]propyl]ethylamine Hydrochloride; (R)-N-[1-(1-Naphthyl)ethyl]-3-[4-(trifluoromethyl)phenyl]propylamine Hydrochloride; (R)-1-(Naphthalen-1-yl)-N-(3-(4-(trifluoromethyl)phenyl)propyl)ethan-1-amine Hydrochloride; (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(4-(trifluoromethyl)phenyl)propan-1-amine HCl; (R)-1-(1-Naphthyl)ethylamine derivative hydrochloride; (R)-NEFTPPA Hydrochloride
EINECS	Contact for details

Quality Control

Our production of (R)-n-(1-(Naphthalen-1-Yl)Ethyl)-3-(4-(Trifluoromethyl)Phenyl)Propan-1-Amine Hydrochloride adheres to stringent quality protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity and chiral purity, NMR, and mass spectrometry for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications. Our quality management system is designed to support cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccant or inert atmosphere packaging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.