Description

2-Bromo-1-Fluoro-3-Methyl-4-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development and production of advanced herbicides, fungicides, and pesticides, leveraging the reactivity of the bromo and nitro groups.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic core and halogen substituents.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the introduction of the aryl moiety into more complex systems.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups facilitate substitution reactions for creating diverse chemical libraries.
• Dye and Pigment Intermediate: Used in the synthesis of specialized colorants and photographic chemicals.

Basic Information

Product Name	2-Bromo-1-Fluoro-3-Methyl-4-Nitrobenzene
CAS No.	1427502-92-8
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	1-Bromo-2-fluoro-6-methyl-3-nitrobenzene; 2-Bromo-1-fluoro-3-methyl-4-nitrobenzene; Benzene, 2-bromo-1-fluoro-3-methyl-4-nitro-; 4-Nitro-2-bromo-1-fluoro-3-methylbenzene; 3-Methyl-4-nitro-2-bromofluorobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-Fluoro-3-Methyl-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.