Description

3-Aza-Bicyclo[3.1.1]Heptane Hydrochloride is a high-purity, nitrogen-containing bicyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical scaffold for medicinal chemistry research, enabling the development of novel pharmacologically active molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the creation of new drug candidates and complex chemical libraries.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research.
• Medicinal Chemistry: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained, three-dimensional bicyclic structure.
• Chemical Library Synthesis: Employed in the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening (HTS).
• Agrochemical Research: Acts as a precursor in the development of new crop protection agents and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Academic Research: Utilized in universities and research institutes for methodological studies in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	3-Aza-Bicyclo[3.1.1]Heptane Hydrochloride
CAS No.	1427380-44-6
Molecular Formula	C6H12ClN
Molecular Weight	133.62 g/mol
Synonyms	3-Azabicyclo[3.1.1]heptane hydrochloride; 3-Azabicyclo[3.1.1]heptane, hydrochloride (1:1); 3-Aza-bicyclo[3.1.1]heptane HCl; 1-Azonia-4-ethylidenebicyclo[2.2.1]heptane chloride; Bicyclo[3.1.1]heptan-3-amine hydrochloride; 3-Aminobicyclo[3.1.1]heptane hydrochloride; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 3-Aza-Bicyclo[3.1.1]Heptane Hydrochloride is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ISO standards for pharmaceutical intermediates, and specifications can be aligned with client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.