Description

[1-(2,6-Difluorophenyl)Cyclopropyl]Methanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclopropylamine structure flanked by difluorophenyl substituents. This compound is of significant value in medicinal chemistry for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new therapeutic entities.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new drug candidates, especially in neurology and psychiatry.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Integral for developing robust, scalable manufacturing routes for promising new chemical entities (NCEs).
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme inhibition or receptor binding mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical component for CDMOs offering bespoke synthesis services to the pharmaceutical industry.

Basic Information

Product Name	[1-(2,6-Difluorophenyl)Cyclopropyl]Methanamine Hydrochloride
CAS No.	1427380-04-8
Molecular Formula	C10H12ClF2N
Molecular Weight	219.66 g/mol
Synonyms	1-(2,6-Difluorophenyl)cyclopropanemethanamine hydrochloride; (1-(2,6-Difluorophenyl)cyclopropyl)methanamine HCl; 2,6-Difluoro-α-(cyclopropylmethyl)benzylamine hydrochloride; 1-(2,6-Difluorobenzyl)cyclopropylamine hydrochloride; α-(Cyclopropylmethyl)-2,6-difluorobenzylamine hydrochloride; (1-(2,6-Difluorophenyl)cyclopropyl)methylamine hydrochloride
EINECS	Contact for details

Quality Control

Our [1-(2,6-Difluorophenyl)Cyclopropyl]Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.