Description

2-(3,3-Difluorocyclobutyl)Ethan-1-Amine Hydrochloride is a high-purity organic salt featuring a difluorocyclobutyl moiety, a valuable scaffold in modern medicinal chemistry. This compound serves as a critical building block for the synthesis of novel pharmaceutical candidates, particularly in the development of small molecule therapeutics. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorinated cyclobutane structures into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disease targets.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorinated cyclobutane group can enhance biological activity and environmental stability.
• Ligand & Probe Development: Serves as a precursor for creating specialized chemical probes and ligands in biochemical and pharmacological research.
• Material Science: Potential building block for advanced polymers and liquid crystals, where the rigid cyclobutane core can influence material properties.
• Fluorine Chemistry Library Synthesis: An essential component for constructing diverse compound libraries focused on fluorine-containing motifs for high-throughput screening.

Basic Information

Product Name	2-(3,3-Difluorocyclobutyl)Ethan-1-Amine Hydrochloride
CAS No.	1427173-51-0
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	2-(3,3-Difluorocyclobutyl)ethanamine hydrochloride; 1-(2-Aminoethyl)-3,3-difluorocyclobutane hydrochloride; 3,3-Difluorocyclobutaneethylamine hydrochloride; 2-(3,3-Difluorocyclobutyl)ethylamine HCl; (3,3-Difluorocyclobutyl)ethanamine hydrochloride; 1427173-51-0; 2-(3,3-Difluorocyclobut-1-yl)ethan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(3,3-Difluorocyclobutyl)Ethan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.