Description

n-Methyl-1-(5-Methyl-4-Phenyl-4H-1,2,4-Triazol-3-Yl)Methanamine Dihydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant commercial and research interest. Its value lies in its critical role as a key building block for the synthesis of advanced pharmaceutical compounds, particularly in antiviral drug discovery and development programs. This compound is essential for R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral therapies.
• Antiviral Drug Research: Used as a key scaffold in medicinal chemistry for the discovery and optimization of new drug candidates targeting viral replication.
• Process Chemistry & Scale-Up: Employed in process development and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in biochemical assays and studies to understand enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis: A starting material for the custom synthesis of specialized chemical entities and complex molecular libraries for high-throughput screening.

Basic Information

Product Name	n-Methyl-1-(5-Methyl-4-Phenyl-4H-1,2,4-Triazol-3-Yl)Methanamine Dihydrochloride
CAS No.	1426290-88-1
Molecular Formula	C12H17Cl2N5
Molecular Weight	310.20 g/mol
Synonyms	1-(5-Methyl-4-phenyl-4H-1,2,4-triazol-3-yl)-N-methylmethanamine dihydrochloride; N-Methyl-1-(5-methyl-4-phenyl-4H-1,2,4-triazol-3-yl)methanamine dihydrochloride; 1426290-88-1; Methanamine, N-methyl-1-(5-methyl-4-phenyl-4H-1,2,4-triazol-3-yl)-, dihydrochloride; NNRTI Intermediate Dihydrochloride Salt; Triazole-based Amine Dihydrochloride
EINECS	Contact for details

Quality Control

Our n-Methyl-1-(5-Methyl-4-Phenyl-4H-1,2,4-Triazol-3-Yl)Methanamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.