Description

Dbco-C6-Acid CAS NO 1425485-72-8 is a bifunctional linker molecule featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a terminal carboxylic acid for further conjugation. This compound is essential for creating stable, catalyst-free bioconjugates in complex biological systems without the need for cytotoxic copper catalysts. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science, enabling precise and efficient labeling of biomolecules.

Application

• Antibody-Drug Conjugate (ADC) Payload Linkage: Conjugation of cytotoxic drugs to monoclonal antibodies via the carboxylic acid group, utilizing the DBCO click chemistry for site-specific attachment.
• Fluorescent Probe and Diagnostic Reagent Synthesis: Labeling peptides, proteins, or oligonucleotides with fluorophores or other reporter molecules for imaging and detection assays.
• Polymer and Biomaterial Functionalization: Introducing bio-orthogonal reactive handles onto surfaces, hydrogels, or nanoparticles for subsequent immobilization of biomolecules.
• Protein and Enzyme Modification: Site-specific PEGylation or crosslinking to enhance stability, solubility, or pharmacokinetic properties of therapeutic proteins.
• Small Molecule Prodrug Development: Creating cleavable linkers for targeted drug delivery systems that release active pharmaceutical ingredients (APIs) at specific sites.
• Chemical Biology and Proteomics Research: As a versatile tool for labeling and identifying newly synthesized proteins or studying protein-protein interactions in live cells.

Basic Information

Item	Details
Product Name	Dbco-C6-Acid
CAS No.	1425485-72-8
Molecular Formula	C24H25NO3
Molecular Weight	375.46 g/mol
Synonyms	DBCO-C6-COOH; DBCO-PEG6-acid; 1-(6-Carboxyhexyl)-1,4,7,10,13,16-hexaoxa-19-azacyclohenicos-19-yne-2,5,8,11,14,17-hexaone; Dibenzocyclooctyne-C6-acid; DBCO-hexanoic acid; DBCO-6-Acid; Azadibenzocyclooctyne-C6-acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yne-9-methyl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate (related structure)
EINECS	Contact for details

Quality Control

Our Dbco-C6-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by NMR)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.