Description

8-Bromo-5-Fluoro-2-(Trifluoromethyl)Quinoline is a high-value, multi-functionalized quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique halogenated and trifluoromethylated structure makes it an indispensable intermediate for the development of novel pharmaceuticals and agrochemicals, particularly in the creation of active ingredients with enhanced metabolic stability and bioavailability. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the fluorine and bromine atoms for bioactivity.
• Material Science Research: Precursor for the synthesis of organic semiconductors, liquid crystals, and fluorescent dyes.
• Cross-Coupling Reactions: Serves as an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromine atom.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and for introducing the trifluoromethyl group, a common pharmacophore.
• Chemical Biology: Potential use as a probe or tag in biochemical assays due to its distinct spectroscopic signature.

Basic Information

Product Name	8-Bromo-5-Fluoro-2-(Trifluoromethyl)Quinoline
CAS No.	1425335-26-7
Molecular Formula	C₁₀H₄BrF₄N
Molecular Weight	294.05 g/mol
Synonyms	8-Bromo-5-fluoro-2-(trifluoromethyl)quinoline; Quinoline, 8-bromo-5-fluoro-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-8-bromo-5-fluoroquinoline; 5-Fluoro-8-bromo-2-trifluoromethylquinoline; 8-Br-5-F-2-CF3-Quinoline
EINECS	Contact for details

Quality Control

Every batch of 8-Bromo-5-Fluoro-2-(Trifluoromethyl)Quinoline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.