Description

(2S)-2-(Difluoromethyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its core value lies in the incorporation of the difluoromethyl group and the stereochemically defined pyrrolidine scaffold, which are critical motifs in modern medicinal chemistry for modulating the physicochemical and metabolic properties of drug candidates. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on discovering novel bioactive molecules, protease inhibitors, and advanced fine chemicals.

Application

• Key chiral intermediate in the synthesis of pharmaceutical active ingredients (APIs), especially those targeting neurological and metabolic diseases.
• Versatile building block for constructing protease and enzyme inhibitors, leveraging the pyrrolidine core as a privileged scaffold.
• Precursor in the research and development of agrochemicals, where the difluoromethyl group can enhance biological activity and stability.
• Critical reagent in asymmetric synthesis and method development for introducing fluorinated motifs into complex molecules.
• Starting material for the preparation of ligands and catalysts used in enantioselective transformations.
• Intermediate in the discovery of diagnostic agents and positron emission tomography (PET) tracers.

Basic Information

Item	Details
Product Name	(2S)-2-(Difluoromethyl)Pyrrolidine Hydrochloride
CAS No.	1423015-69-3
Molecular Formula	C5H10F2N·HCl
Molecular Weight	169.60 g/mol (Free base: 134.14 g/mol)
Synonyms	(S)-2-(Difluoromethyl)pyrrolidine hydrochloride; (2S)-2-(Difluoromethyl)-1-azacyclopentane hydrochloride; (S)-2-(Difluoromethyl)pyrrolidine HCl; L-2-(Difluoromethyl)pyrrolidine hydrochloride; (S)-(-)-2-(Difluoromethyl)pyrrolidine hydrochloride; Pyrrolidine, 2-(difluoromethyl)-, hydrochloride, (2S)-; 1423015-69-3
EINECS	Contact for details

Quality Control

Our (2S)-2-(Difluoromethyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.