Description

7-Oxo-5-Thiaspiro[3.4]Octane-6-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic thiaheterocyclic scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting complex disease pathways. It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry and process R&D for new drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery programs, especially for central nervous system (CNS) and anti-infective targets.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis due to its constrained spirocyclic architecture.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for candidate drugs requiring this specific heterocyclic core.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for studying novel heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	7-Oxo-5-Thiaspiro[3.4]Octane-6-Carboxylic Acid Ethyl Ester
CAS No.	1422354-53-7
Molecular Formula	C9H12O3S
Molecular Weight	200.25 g/mol
Synonyms	Ethyl 7-oxo-5-thiaspiro[3.4]octane-6-carboxylate; 5-Thiaspiro[3.4]octane-6-carboxylic acid, 7-oxo-, ethyl ester; 7-Oxo-5-thiaspiro[3.4]octane-6-carboxylic acid ethyl ester; Spiro[thiophene-3,1'-cyclobutane] derivative
EINECS	Contact for details

Quality Control

Our 7-Oxo-5-Thiaspiro[3.4]Octane-6-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development needs with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.