Description

tert-Butyl 2-(Iodomethyl)-1,7-dioxa-10-azaspiro[4.6]undecane-10-carboxylate is a sophisticated, high-purity organic intermediate featuring a unique spirocyclic structure. This compound is critical for its role as a versatile building block in advanced pharmaceutical synthesis and complex organic chemistry research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those containing spirocyclic or constrained ring systems.
• Medicinal Chemistry Research: Used in the discovery and development of new drug candidates, enabling structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetic Synthesis: Serves as a precursor for creating peptidomimetics and macrocyclic compounds, which are important in developing protease inhibitors and other therapeutic agents.
• Agrochemical Development: Intermediate in the research and production of advanced crop protection agents and pesticides with novel modes of action.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and enzyme functions.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, including cross-coupling reactions and functional group transformations.

Basic Information

Item	Details
Product Name	tert-Butyl 2-(Iodomethyl)-1,7-dioxa-10-azaspiro[4.6]undecane-10-carboxylate
CAS No.	1422344-13-5
Molecular Formula	C14H24INO4
Molecular Weight	397.25 g/mol
Synonyms	10-Boc-2-(iodomethyl)-1,7-dioxa-10-azaspiro[4.6]undecane; tert-Butyl 2-(iodomethyl)-1,7-dioxa-10-azaspiro[4.6]undecane-10-carboxylate; Boc-protected iodomethyl spirocyclic ketal; 2-(Iodomethyl)-1,7-dioxa-10-azaspiro[4.6]undecane-10-carboxylic acid tert-butyl ester; 1,7-Dioxa-10-azaspiro[4.6]undecane-10-carboxylic acid, 2-(iodomethyl)-, 1,1-dimethylethyl ester; Spirocyclic Boc-amine iodo derivative
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 2-(Iodomethyl)-1,7-dioxa-10-azaspiro[4.6]undecane-10-carboxylate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. All materials are characterized using advanced analytical techniques, including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.