Description

Rel-(3As,7R,8As)-2-(Pyridin-4-Ylmethyl)Octahydro-3A,7-Epoxyisothiazolo[4,5-C]Azepine 1,1-Dioxide is a high-purity, advanced pharmaceutical intermediate featuring a complex, conformationally constrained heterocyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly those targeting the central nervous system. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for use in lead optimization and scalable synthetic routes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead compound optimization due to its unique fused bicyclic scaffold.
• Process Chemistry Development: Serves as a critical intermediate for developing robust, scalable GMP manufacturing processes for active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study biological pathways and protein-ligand interactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharma industry.
• Academic Research: Employed in university and institutional labs for cutting-edge research in organic synthesis and drug discovery methodologies.

Basic Information

Item	Details
Product Name	Rel-(3As,7R,8As)-2-(Pyridin-4-Ylmethyl)Octahydro-3A,7-Epoxyisothiazolo[4,5-C]Azepine 1,1-Dioxide
CAS No.	1422068-32-3
Molecular Formula	C16H21N3O3S
Molecular Weight	335.42 g/mol
Synonyms	(3aR,7R,8aS)-2-((Pyridin-4-yl)methyl)hexahydro-3a,7-epoxy[1,2]thiazolo[4,5-c]azepine 1,1-dioxide; Rel-2-((Pyridin-4-yl)methyl)octahydro-3a,7-epoxyisothiazolo[4,5-c]azepine 1,1-dioxide; (3aR,7R,8aS)-2-(Pyridin-4-ylmethyl)-3a,4,5,6,7,8,8a,9-octahydro-3a,7-epoxy[1,2]thiazolo[4,5-c]azepine 1,1-dioxide; Bicyclic Sulfonamide-Pyridine Intermediate; 1422068-32-3
EINECS	Contact for details

Quality Control

Every batch of Rel-(3As,7R,8As)-2-(Pyridin-4-Ylmethyl)Octahydro-3A,7-Epoxyisothiazolo[4,5-C]Azepine 1,1-Dioxide is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity consistent with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and full characterization data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.