Description

tert-Butyl 2-Chloro-4-Methyl-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate CAS NO 1421254-01-4 is a high-purity, advanced pharmaceutical intermediate characterized by its naphthyridine core structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Oncology Drug Development: Used in the synthesis of potential kinase inhibitors and other targeted cancer therapies due to its privileged heterocyclic structure.
• CNS-Active Compound Synthesis: Employed in creating candidates for neurological disorders, leveraging the naphthyridine moiety's ability to interact with biological targets.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	tert-Butyl 2-Chloro-4-Methyl-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate
CAS No.	1421254-01-4
Molecular Formula	C15H19ClN2O2
Molecular Weight	294.78 g/mol
Synonyms	tert-Butyl 2-chloro-4-methyl-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate; 6-Boc-2-chloro-4-methyl-5,6,7,8-tetrahydro-1,6-naphthyridine; 2-Chloro-4-methyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylic acid tert-butyl ester; 2-Chloro-4-methyl-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylic acid tert-butyl ester; tert-Butyl 2-chloro-4-methyl-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate; 1421254-01-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Chloro-4-Methyl-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are provided and available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.