Description

(3S)-1-(Pyrimidin-2-Yl)Pyrrolidin-3-Amine Hydrochloride is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially for central nervous system (CNS) and antiviral targets.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex pyrrolidine- and pyrimidine-containing scaffolds.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis.
• Academic and Industrial Research: Employed in chemical biology and structure-activity relationship (SAR) studies.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for advanced intermediates.

Basic Information

Item	Details
Product Name	(3S)-1-(Pyrimidin-2-Yl)Pyrrolidin-3-Amine Hydrochloride
CAS No.	1421026-05-2
Molecular Formula	C8H13N5•HCl
Molecular Weight	215.68 g/mol
Synonyms	(3S)-1-(2-Pyrimidinyl)-3-pyrrolidinamine hydrochloride; (S)-1-(Pyrimidin-2-yl)pyrrolidin-3-amine hydrochloride; 1-(Pyrimidin-2-yl)-(3S)-pyrrolidin-3-amine HCl; 1421026-05-2; (3S)-1-(2-Pyrimidinyl)-3-pyrrolidinamine HCl; (S)-3-Amino-1-(pyrimidin-2-yl)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (3S)-1-(Pyrimidin-2-Yl)Pyrrolidin-3-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.