Description

5,5-Difluorooxan-3-Amine is a high-purity, specialized fluorinated building block of significant interest in advanced chemical synthesis. This compound matters for its unique structural motif, which incorporates both an amine and a difluorinated oxane ring, making it a valuable precursor for introducing fluorine atoms into complex molecular architectures. Pharmaceutical, agrochemical, and material science researchers need it for the development of novel active ingredients and functional materials, where fluorination is a key strategy to modulate properties like metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, protease inhibitors, and CNS-active compounds.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides, where the fluorine atoms can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for fluorinated polymers, liquid crystals, or advanced coatings with tailored surface properties and improved chemical resistance.
• Chemical Biology Probe Development: Employed in the synthesis of fluorinated analogs of biomolecules for use in imaging, diagnostics, and mechanistic studies.
• Organic Synthesis Reagent: Acts as a versatile intermediate in multi-step synthetic routes for constructing complex, fluorinated heterocycles and natural product analogs.

Basic Information

Product Name	5,5-Difluorooxan-3-Amine
CAS No.	1418199-75-3
Molecular Formula	C5H9F2NO
Molecular Weight	137.13 g/mol
Synonyms	3-Amino-5,5-difluorotetrahydro-2H-pyran; 5,5-Difluorotetrahydro-2H-pyran-3-amine; 5,5-Difluorooxan-3-amine; Tetrahydro-2H-pyran-3-amine, 5,5-difluoro-; 3-Amino-5,5-difluorotetrahydropyran
EINECS	Contact for details

Quality Control

Our 5,5-Difluorooxan-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid or clear to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.