Description

4-(3-Fluoro-Benzenesulfonylmethyl)-Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its distinct sulfonylmethyl-piperidine structure. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific enzymes due to the sulfonylmethyl-piperidine moiety.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways.
• Medicinal Chemistry Optimization: Employed in structure-activity relationship (SAR) studies to fine-tune the pharmacokinetic and pharmacodynamic properties of lead molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and novel methodology development.

Basic Information

Product Name	4-(3-Fluoro-Benzenesulfonylmethyl)-Piperidine Hydrochloride
CAS No.	1417793-33-9
Molecular Formula	C13H17FNO2S • HCl
Molecular Weight	305.80 g/mol (Free base: 269.34 g/mol)
Synonyms	4-[(3-Fluorophenyl)sulfonylmethyl]piperidine hydrochloride; 1-[(3-Fluorophenyl)sulfonylmethyl]-4-piperidine hydrochloride; Piperidine, 4-[(3-fluorophenyl)sulfonylmethyl]-, hydrochloride; 4-(3-Fluorobenzenesulfonylmethyl)piperidine HCl; 1417793-33-9; 4-(3-Fluoro-phenylsulfonylmethyl)-piperidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 4-(3-Fluoro-Benzenesulfonylmethyl)-Piperidine Hydrochloride is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and MS, to ensure compliance with exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.