Description

5-(1-tert-Butoxycarbonyl-Pyrrolidin-3-Ylcarbamoyl)-3H-Imidazole-4-Carboxylic Acid is a sophisticated heterocyclic building block designed for advanced pharmaceutical synthesis. This compound is valued for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting complex biological pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the production of high-value therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for the reliable and scalable production of target APIs under current Good Manufacturing Practice (cGMP) standards.
• Bioconjugation & Probe Development: The reactive carboxylic acid and protected amine functionalities make it suitable for creating labeled compounds or conjugates for biochemical research.
• Peptidomimetic Synthesis: Integral to the construction of peptidomimetic scaffolds that mimic natural peptides but with enhanced metabolic stability and bioavailability.

Basic Information

Product Name	5-(1-tert-Butoxycarbonyl-Pyrrolidin-3-Ylcarbamoyl)-3H-Imidazole-4-Carboxylic Acid
CAS No.	1417793-25-9
Molecular Formula	C14H20N4O5
Molecular Weight	324.33 g/mol
Synonyms	5-[(3-{[(tert-Butoxy)carbonyl]amino}pyrrolidin-1-yl)carbonyl]-1H-imidazole-4-carboxylic acid; 1H-Imidazole-4-carboxylic acid, 5-[[3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-pyrrolidinyl]carbonyl]-; Boc-3-amino-pyrrolidine imidazole-4-carboxylic acid derivative; tert-Butyl (1-(4-carboxy-1H-imidazol-5-yl)carbonyl)pyrrolidin-3-yl)carbamate; CAS 1417793-25-9
EINECS	Contact for details

Quality Control

Our production of 5-(1-tert-Butoxycarbonyl-Pyrrolidin-3-Ylcarbamoyl)-3H-Imidazole-4-Carboxylic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider conditions under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.