Description

1-Bromo-2-(Difluoromethoxy)-5-Fluoro-4-Nitro-Benzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromo, difluoromethoxy, fluoro, and nitro substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Serves as a critical building block for developing new herbicides, fungicides, and insecticides, where the fluorine and difluoromethoxy groups enhance biological activity and metabolic stability.
• Material Science Research: Used in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-withdrawing nitro and halogen groups.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis, enabling novel cross-coupling and other transformative reactions.
• Fluorinated Compound Library: An essential substrate for creating diverse fluorinated compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	1-Bromo-2-(Difluoromethoxy)-5-Fluoro-4-Nitro-Benzene
CAS No.	1417566-72-3
Molecular Formula	C7H3BrF3NO3
Molecular Weight	293.01 g/mol
Synonyms	2-Bromo-1-(difluoromethoxy)-4-fluoro-5-nitrobenzene; 5-Fluoro-4-nitro-2-(difluoromethoxy)bromobenzene; Benzene, 1-bromo-2-(difluoromethoxy)-5-fluoro-4-nitro-; 1417566-72-3; 1-Bromo-2-(difluoromethoxy)-5-fluoro-4-nitrobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(Difluoromethoxy)-5-Fluoro-4-Nitro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.