Description

(4-(1,2,4,5-Tetrazin-3-Yl)Phenyl)Methanamine Hcl is a high-purity, heterocyclic amine derivative with a tetrazine functional group, serving as a critical building block in advanced chemical synthesis. Its core value lies in its role as a versatile linker and precursor for bioorthogonal chemistry and materials science applications. This compound is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and polymer industries who require reliable, high-quality intermediates for developing targeted therapies and functional materials.

Application

• Bioorthogonal Chemistry: A key reagent for inverse electron-demand Diels-Alder (IEDDA) click chemistry, enabling site-specific labeling and conjugation of biomolecules like antibodies, proteins, and oligonucleotides.
• Pharmaceutical Intermediates: Serves as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs) and targeted drug delivery systems.
• Bioconjugation & Probe Development: Used to create fluorescent probes, imaging agents, and diagnostic tools for in vitro and in vivo applications.
• Materials Science & Polymer Chemistry: Functions as a cross-linking agent or functional monomer for synthesizing advanced polymers, hydrogels, and smart materials with specific responsive properties.
• Chemical Biology Research: Enables the study of biomolecular interactions and cellular processes through selective labeling and tagging strategies.
• Agrochemical Synthesis: A potential intermediate in the development of new crop protection agents and specialty agrochemicals.

Basic Information

Product Name	(4-(1,2,4,5-Tetrazin-3-Yl)Phenyl)Methanamine Hcl
CAS No.	1416711-59-5
Molecular Formula	C9H10ClN5
Molecular Weight	223.66 g/mol
Synonyms	1-(4-Aminomethylphenyl)-1,2,4,5-tetrazine hydrochloride; 4-(1,2,4,5-Tetrazin-3-yl)benzylamine hydrochloride; TETRAZINE-PEG4-AMINE HCL (related derivative); Tetrazinylbenzylamine HCl; 3-(4-(Aminomethyl)phenyl)-1,2,4,5-tetrazine hydrochloride; Bioorthogonal Amine Linker; IEDDA Amine Reagent; Tetrazine-Amine Conjugation Reagent
EINECS	Contact for details

Quality Control

Our (4-(1,2,4,5-Tetrazin-3-Yl)Phenyl)Methanamine Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure compliance with exacting research and production standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.