Description

(R)-3-(Boc-Amino)Pyrrolidine Hydrochloride is a high-purity chiral building block and protected amine intermediate essential for modern pharmaceutical synthesis. This compound matters because it provides a stereochemically defined pyrrolidine scaffold, a privileged structure in drug discovery for creating bioactive molecules. Pharmaceutical R&D and fine chemical manufacturers need it for the efficient production of active pharmaceutical ingredients (APIs), particularly in developing protease inhibitors, neurological agents, and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug molecules, including protease inhibitors and kinase inhibitors.
• Peptidomimetics & PROTACs: Serves as a crucial component in designing peptide mimics and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• API Development: Integral in the research and scale-up phases for developing new Active Pharmaceutical Ingredients (APIs) with defined stereochemistry.
• Chemical Biology Probes: Employed in the construction of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Research: Potential intermediate in the development of chiral agrochemicals requiring specific biological activity.

Basic Information

Product Name	(R)-3-(Boc-Amino)Pyrrolidine Hydrochloride
CAS No.	1416450-63-9
Molecular Formula	C9H19ClN2O2
Molecular Weight	222.71 g/mol
Synonyms	(R)-1-Boc-3-Aminopyrrolidine Hydrochloride; (R)-3-[(tert-Butoxycarbonyl)amino]pyrrolidine Hydrochloride; (R)-N-Boc-3-Aminopyrrolidine HCl; (R)-3-Amino-1-Boc-pyrrolidine Hydrochloride; tert-Butyl (R)-3-aminopyrrolidine-1-carboxylate hydrochloride; (R)-3-(Boc-amino)pyrrolidine HCl; (3R)-3-[(2-Methylpropan-2-yl)oxycarbonylamino]pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-(Boc-Amino)Pyrrolidine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.