Description

tert-Butyl 9-(2-Ethoxy-2-oxoethyl)-3-azaspiro[5.5]undecane-3-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and ester-functionalized structure. This compound is critical for enabling sophisticated synthetic routes in medicinal chemistry, particularly for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially those with spirocyclic architectures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• API Development: Serves as a precursor in the production of complex active pharmaceutical ingredients for clinical trials and commercial manufacturing.
• Neurological Drug Synthesis: Particularly relevant in the synthesis of compounds targeting central nervous system (CNS) pathways.
• Process Chemistry: Employed in route scouting and scale-up processes for efficient and cost-effective API production.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical services.

Basic Information

Product Name	tert-Butyl 9-(2-Ethoxy-2-oxoethyl)-3-azaspiro[5.5]undecane-3-carboxylate
CAS No.	1416176-19-6
Molecular Formula	C18H31NO4
Molecular Weight	325.45 g/mol
Synonyms	3-Azaspiro[5.5]undecane-3-carboxylic acid, 9-(2-ethoxy-2-oxoethyl)-, 1,1-dimethylethyl ester; tert-Butyl 9-(ethoxyoxaloethyl)-3-azaspiro[5.5]undecane-3-carboxylate; 9-(2-Ethoxy-2-oxoethyl)-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester; 1416176-19-6; Spirocyclic tert-butyl ester intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 9-(2-Ethoxy-2-oxoethyl)-3-azaspiro[5.5]undecane-3-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.