Description

1,8-Diazaspiro[4.5]Dec-3-En-2-One, 1-(3-Fluorophenyl)-7-Methyl-, Hydrochloride (1:1), (5R,7S)- is a high-purity, stereochemically defined pharmaceutical intermediate with the CAS number 1416161-79-9. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and psychiatric disorders. It is primarily sought by research institutions, custom synthesis organizations, and pharmaceutical companies engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) targets.
• Preclinical & Clinical Research: Used to synthesize reference standards and batches for pharmacological evaluation, toxicology studies, and early-phase clinical trials.
• Process Chemistry Development: Serves as a starting material or advanced intermediate for optimizing scalable synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Employed in medicinal chemistry programs to explore structure-activity relationships (SAR) and develop novel spirocyclic and diazepine-based compounds.
• Custom Synthesis: Supplied to contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring this precise molecular scaffold.

Basic Information

Product Name	1,8-Diazaspiro[4.5]Dec-3-En-2-One, 1-(3-Fluorophenyl)-7-Methyl-, Hydrochloride (1:1), (5R,7S)-
CAS No.	1416161-79-9
Molecular Formula	C15H18FN2O • HCl
Molecular Weight	298.78 g/mol
Synonyms	(5R,7S)-1-(3-Fluorophenyl)-7-methyl-1,8-diazaspiro[4.5]dec-3-en-2-one hydrochloride; (5R,7S)-1-(3-Fluorophenyl)-7-methyl-1,8-diazaspiro[4.5]dec-3-en-2-one HCl; 1-(3-Fluorophenyl)-7-methyl-1,8-diazaspiro[4.5]dec-3-en-2-one hydrochloride (5R,7S)-; UNII-Contact for details; 1416161-79-9; (5R,7S)-enantiomer of 1-(3-Fluorophenyl)-7-methyl-1,8-diazaspiro[4.5]dec-3-en-2-one hydrochloride
EINECS	Contact for details

Quality Control

Our 1,8-Diazaspiro[4.5]Dec-3-En-2-One, 1-(3-Fluorophenyl)-7-Methyl-, Hydrochloride (1:1), (5R,7S)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to confirm stereochemical purity and identity. Certificates of Analysis (COA) are provided, detailing purity, impurity profiles, and residual solvents. We support development from research to GMP-grade material, with specifications tailored to your phase-appropriate requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.