Description

1-Bromo-5-Fluoro-4-Methanesulfonyl-2-Nitrobenzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromo, fluoro, methanesulfonyl, and nitro substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogen and sulfone groups for bioactivity.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups allow for selective nucleophilic substitution, enabling the introduction of various amines, alkoxides, and thiols.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening for generating diverse compound libraries in drug discovery programs.

Basic Information

Product Name	1-Bromo-5-Fluoro-4-Methanesulfonyl-2-Nitrobenzene
CAS No.	1415819-92-9
Molecular Formula	C7H5BrFNO4S
Molecular Weight	298.09 g/mol
Synonyms	2-Bromo-4-fluoro-5-nitrobenzenesulfonylmethane; 4-Bromo-2-fluoro-1-methanesulfonyl-5-nitrobenzene; 1-Bromo-5-fluoro-4-(methylsulfonyl)-2-nitrobenzene; 5-Bromo-2-fluoro-4-(methylsulfonyl)nitrobenzene; Benzenesulfonylmethane, 2-bromo-4-fluoro-5-nitro-; Benzene, 1-bromo-5-fluoro-4-(methylsulfonyl)-2-nitro-; CAS 1415819-92-9
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Fluoro-4-Methanesulfonyl-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening containers to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.